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This study was deed to examine the fibrogenic and carcinogenic potentials of three smelter slags primary copper slag, secondary copper slag, and nickel slag that have been used for a of years as substitutes for sand in abrasive blasting operations. Seven groups of 85 male Fischer rats approximately g were used. Each group was given a single mg dose of one of the following test materials via intratracheal instillation: primary copper slag, secondary copper slag, nickel slag, feldspar, Min-U-Sil, novaculite, or vehicle control. Chemical, particle size, and surface area analyses were performed slags numbers each test dust.
Animals were weighed monthly, and ten animals per group were necropsied at the 6-,and mo interim sacrifices. The terminal sacrifice was conducted at 22 mo. Hematoxylin and eosin stained histologic sections were prepared from slags numbers formalin-fixed tissues collected at necropsy and examined microscopically. The pulmonary fibrogenic and carcinogenic potentials of the three smelter slags were compared histopathologically with feldspar, novaculite, Min-U-Sil, and vehicle controls.
Only minimal to slight alveolar wall fibrosis was seen in the two copper slag groups, while the response seen with nickel slag was consistent with a foreign body reaction with minimal fibrosis seen in only an occasional animal. The major reaction seen in both the feldspar- and the novaculite-treated rats was a granulomatous inflammation with varying degrees of fibrosis associated with the granulomas.
In addition, the Min-U-Sil and novaculite groups had ificantly elevated pulmonary tumor proportions relative to the other treatments p less than or equal to 0. On the basis of the tumor incidence data, one must conclude that both copper slags tested in this study are carcinogenic to rats. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable.
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Cite Display options Display options. Abstract This study was deed to examine the fibrogenic and carcinogenic potentials of three smelter slags primary copper slag, secondary copper slag, and nickel slag that have been used for a of years as substitutes for sand in abrasive blasting operations. Similar articles Fibrogenic potentials of coal slags used as abrasive blasting substitutes. Stettler LE, et al. J Toxicol Environ Health. PMID: Fibrogenic potential of slags used as substitutes for sand in abrasive blasting operations. Mackay GR, et al. Am Ind Hyg Assoc J.
Comparative pulmonary toxicity of blasting sand and five substitute abrasive slags numbers agents. Porter DW, et al. J Toxicol Environ Health A. National Toxicology Program. Metal losses in pyrometallurgical operations - A review. Bellemans I, et al. Adv Colloid Interface Sci. Epub Aug PMID: Review. See all similar articles. Cited by 1 article Elemental properties of copper slag and measured airborne exposures at a copper slag processing facility.
Mugford C, et al. J Occup Environ Hyg. Animals Actions. Dust Actions. Environmental Exposure Actions. Particle Size Actions.
Rats Actions. Rats, Inbred F Actions. Staining and Labeling Actions. Surface Properties Actions. Substances Air Pollutants, Occupational Actions.
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